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KMID : 1103720110640010001
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Journal of the Korean Society of Radiology
2011 Volume.64 No. 1 p.1 ~ p.9
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The Susceptibility Vessel Sign of the Middle Cerebral Artery on the T2*-Weighted Gradient Echo Imaging: Semi-quantification to Predict the Response to Multimodal Intra-Arterial Thrombolysis
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Youn Sung-Won
Jung Cheol-Kyu
Choi Byung-Se
Kim Jae-Hyoung
Kwon O-Ki
Han Moon-Ku
Bae Hee-Joon
Kwon Bae-Ju
Han Moon-Hee
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Abstract
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Purpose: We wanted to determine whether or not the “susceptibility asymmetry index” (SAI) of acute stroke on the T2*-weighted image is related with successful recanalization using multimodal intra-arterial thrombolysis (IAT).
Materials and Methods: The 81 patients who underwent multimodal IAT for middle cerebral artery (MCA) territory acute stroke were included in this retrospective study. The multimodal IAT included intra-arterial urokinase infusion, clot disruption by a microwire, microcatheter and balloon manipulation, and balloon angioplasty and/or stenting for the flow-limiting stenosis. The diameter of the susceptibility vessel sign was measured on the T2*-weighted gradient echo imaging (GRE), and the diameter of the contralateral normal MCA at the corresponding level was measured on magnetic resonance angiography (MRA); the ratio between these two diameters was defined as the susceptibility asymmetry index. The relation between the TICI (Thrombolysis In Cerebral Infarction) score of 2-3 after multimodal IAT and the SAI was assessed. The receiver operating characteristic (ROC) curve analysis was performed on the SAI to predict a TICI score of 2-3 after multimodal IAT.
Results: The mean SAI of 81 patients was 1.66 ± 0.66. Seventy nine percent of the patients had a TICI of 2-3 after multimodal IAT. According to the ROC curve analysis, an SAI less than 1.3 was optimal for predicting the presence of stenotic lesion after recanalization (area under the curve: 0.821, sensitivity: 88.2%, specificity: 69.8%, p=0.0001), and the SAI ≤1.61 (area under the curve: 0.652, sensitivity: 60.9%, specificity: 70.6%, p=0.0226) could predict a TICI score of 2-3. The TICI score of 2-3 after multimodal IAT was achieved in 88.6% of the cases with a SAI ≤ 1.61 and in 67.6% of the cases with a SAI >1.61 (p=0.028).
Conclusion: The lower SAI on T2*-GRE could predict stenotic lesion and successful recanalization after performing IAT.
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KEYWORD
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Stroke, Magnetic Resonance Imaging, Middle Cerebral Artery, Thrombolytic Therapy
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